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| Eleotério,R.B.; Pontes,K.C.S.; Machado,J.P.; Reis,E.C.C.; Ferreira,P.S.; Silva,M.B.; Martins,N.J.S.; Fernandes,N.A.; Borges,A.P.B.. |
| Chondroitin and glucosamine sulfate nutraceuticals are commonly used in the management of degenerative articular disease in veterinary routine. However, there are controversies on the contribution of these substances to articular cartilage. The purpose of this study was to evaluate the efficiency of a chondroitin and glucosamine sulfate-based veterinary nutraceutical on the repair of an induced osteochondral defect in a dog femoral condyle, by macroscopic, histological and histomorphometric analyses. The nutraceutical was orally administered the day following injury induction, every 24 hours (treated group, TG, n=24), compared with animals that did not receive the product (control group, CG, n=24). Six animals per group were anaesthetized for sample... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Degenerative articular disease; Osteoarthritis; Arthrosis; Chondroprotective; Cartilage. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000200325 |
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| Khan,Muhammad Imran; Madni,Asadullah; Ahmad,Saeed; Mahmood,Muhammad Ahmad; Rehman,Mubashar; Ashfaq,Muhammad. |
| Diacerein is used for symptomatic relief and cartilage regeneration in osteoarthritis. Due to gastrointestinal side effects, poor aqueous solubility and low bioavailability, its clinical usage has been restricted. The objective of the present study was to enhance its dissolution profile and to attain sustained release by designing a novel delivery system based on niosomes. Five niosomal formulations (F1-F5) with non-ionic surfactant (sorbitan monostearate) and cholesterol in varying ratios of 5:5, 6:4, 7:3, 8:2 and 9:1 were developed by the reverse-phase evaporation technique. The size and polydispersivity index (PDI) were found in the range of 0.608 µm to 1.010 µm and 0.409 to 0.781, respectively. Scanning electron microscopy (SEM) of the selected... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chondroprotective; Diacerein/dissolution profile; Diacerein/sustained release; Niosomes; Sorbitan monostearate; Reverse-phase evaporation. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300607 |
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